Olfactory dysfunction and functional connectivity changes in cognitively normal Parkinson’s disease

In this study, we investigated brain atrophic changes and functional connectivity alterations in Parkinson’s disease patients with severe hyposmia, patients with no/mild hyposmia, and healthy controls. All patients were assessed using Odor Stick Identification Test for the Japanese (OSIT-J) and Addenbroke’s Cognitive Examination-Revised (ACE-R) for their odor-identification performance and general cognitive function, respectively. We used resting state functional magnetic resonance imaging to evaluate functional connectivity.

Tasks:

001 rest eyes closed

Investigators:

  • Noritaka Yoneyama
  • Hirohisa Watanabe
  • Kazuya Kawabata
  • Epifanio Bagarinao
  • Kazuhiro Hara
  • Takashi Tsuboi
  • Yasuhiro Tanaka
  • Reiko Ohdake
  • Kazunori Imai
  • Rei Ogura
  • Yasutaka Kato
  • Michihito Masuda
  • Tatsuya Hattori
  • Mizuki Ito
  • Satoshi Maesawa
  • Daisuke Mori
  • Masahisa Katsuno
  • Gen Sobue

Contact Information:

Name: Epifanio Bagarinao
Email: ebagarinao@met.nagoya-u.ac.jp

Acknowledgements and Funding:

This research was supported in part by the following: a Grant-in-Aid from the Research Committee of Central Nervous System Degenerative Diseases by the Ministry of Health, Labour, and Welfare, Integrated Research on Neuropsychiatric Disorders project, carried out by SRBPS; a Grant-in-Aid for Scientific Research on Innovative Areas (Brain Protein Aging and Dementia Control 26117002) from the MEXT of Japan; Integrated Research on Neuropsychiatric Disorders carried out under the Strategic Research Program for Brain Sciences, Scientific Research on Innovative Areas (Comprehensive Brain Science Network); and Integrated Research on Depression, Dementia, and Development Disorders by the Strategic Research Program for Brain Sciences from the Japan Agency for Medical Research and Development (AMED).

Sample Size:

45

Scanner Type:

Siemens Magnetom Verio 3T scanner

License:

CC0

Accession Number:

ds000245

How to cite this dataset:

In addition to any citation requirements in the dataset summary please use the following to cite this dataset:

This data was obtained from the OpenfMRI database. Its accession number is ds000245

Curated:

Yes

Browse Data For All Revisions on S3

Direct Links to data:

Revision: 1.0.0 Date Set: Oct. 27, 2017, 9:56 p.m.

Notes:

- Initial release