Imaging [18F]AV-1451 and [18F]AV-45 in acute and chronic traumatic brain injury

The potential long-term effects of Traumatic Brain Injury (TBI) are poorly understood. Repeated concussions have been associated with an elevated incidence of Alzheimer’s disease (AD) as well as chronic traumatic encephalopathy (CTE). There are growing concerns about the long-term neurologic consequences of head impact exposure from routine participation in contact sports (e.g., boxing, football). Brain autopsies of athletes with confirmed CTE have demonstrated tau-immunoreactive neurofibrillary tangles and neuropil threads (known as tauopathy). The relationship between exposure to repetitive head impact and the subsequent development of chronic neurodegenerative disease has not been established. Further, as the diagnosis of CTE (defined by the presence of tauopathy) is presently made at autopsy, clinical tools and biomarkers for detecting it remain to be defined. We aim to determine whether these individuals are on the same trajectory of neurodegenerative disease seen in AD or in CTE. Our study will utilize both [18F]-AV-1451 and [18F]-T807 PET imaging to investigate amyloid and tau accumulation in subjects with a history of concussions. We will obtain MRI, PET, and neurocognitive data in a cohort of 25 subjects with a history of TBIs and a cohort of 25 controls. This dataset currently contains data acquired from two sessions (3.9 years apart) from a single subject, including two T1w scans and two PET scans.

Investigators:

  • Dara Dickstein
  • Mariel Y. Pullman
  • Corey Fernandez
  • Jennifer A. Short
  • Lale Kostakoglu
  • Karin Knesaurek
  • Laili Soleimani
  • Barry Jordan
  • Wayne Gordon
  • Kristen Dams-O’Connor
  • Bradley N. Delman
  • Edmund Wong
  • Cheuk Y. Tang
  • Steven T. DeKosky
  • James R. Stone
  • Robert C. Cantu
  • Mary Sano
  • Patrick R. Hof
  • Sam Gandy

Contact Information:

Email: samuel.gandy@mssm.edu

Acknowledgements and Funding:

The Alzheimer’s Disease Drug Foundation; NIH grants NINDS 5U01NS086625 and NICHD K01HD074651-01A; The Werber Family Foundation

External Publication Links:

Cerebral [18 F]T807/AV1451 retention pattern in clinically probable CTE resembles pathognomonic distribution of CTE tauopathy

Sample Size:

1

Scanner Type:

Siemens

License:

PDDL

Accession Number:

ds000204

How to cite this dataset:

In addition to any citation requirements in the dataset summary please use the following to cite this dataset:

This data was obtained from the OpenfMRI database. Its accession number is ds000204

Curated:

Yes

Browse Data For All Revisions on S3

Direct Links to data:

Revision: 1.0.2 Date Set: Sept. 16, 2017, 12:02 a.m.

Notes:

- Changed funding into string in dataset_description.json

Revision: 1.0.1 Date Set: July 6, 2016, 12:04 p.m.

Notes:

- Added fields to dataset_description.json
- Fixed formatting issues in pet json files
- Added CHANGES.txt

Revision: 1.0.0 Date Set: June 28, 2016, 1:25 p.m.

Notes:

Initial release