Spinal fMRI reveals decreased descending inhibition during secondary mechanical hyperalgesia

Mechanical hyperalgesia is one distressing symptom of neuropathic pain which is explained by central sensitization of the nociceptive system. This sensitization can be induced experimentally with the heat/capsaicin sensitization model. The aim was to investigate and compare spinal and supraspinal activation patterns of identical mechanical stimulation before and after sensitization using functional spinal magnetic resonance imaging (spinal fMRI).

Sixteen healthy subjects (6 female, 10 male, mean age 27.2 ± 4.0 years) were investigated with mechanical stimulation of the C6 dermatome of the right forearm during spinal fMRI. Testing was always performed in the area outside of capsaicin application (i.e. area of secondary mechanical hyperalgesia).

During slightly noxious mechanical stimulation before sensitization, activity was observed in ipsilateral dorsolateral pontine tegmentum (DLPT) which correlated with activity in ipsilateral spinal cord dorsal gray matter (dGM) suggesting activation of descending nociceptive inhibition. During secondary mechanical hyperalgesia, decreased activity was observed in bilateral DLPT, ipsilateral/midline rostral ventromedial medulla (RVM), and contralateral subnucleus reticularis dorsalis, which correlated with activity in ipsilateral dGM. Comparison of voxel-based activation patterns during mechanical stimulation before/after sensitization showed deactivations in RVM and activations in superficial ipsilateral dGM.

This study revealed increased spinal activity and decreased activity in supraspinal centers involved in pain modulation (SRD, RVM, DLPT) during secondary mechanical hyperalgesia suggesting facilitation of nociception via decreased endogenous inhibition. Results should help prioritize approaches for further in vivo studies on pain processing and modulation in humans.

Tasks:

001 mechanical stimulation

Investigators:

  • Rempe T
  • Wolff S
  • Riedel C
  • Baron R
  • Stroman PW
  • Jansen O
  • Gierthmühlen J

Contact Information:

Name: Torge Rempe
Email: t.rempe@neurologie.uni-kiel.de

Acknowledgements and Funding:

We are indebted to the subjects who participated in the study for their consent and co-operation. The study was supported by the German Federal Ministry of Education and Research (BMBF, 01EM05/04). However, the authors received no specific funding for this work. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

External Publication Links:

Spinal fMRI reveals decreased descending inhibition during secondary mechanical hyperalgesia.

Sample Size:

16

Scanner Type:

Philips Achieva 3T

License:

PDDL

Accession Number:

ds000138

How to cite this dataset:

In addition to any citation requirements in the dataset summary please use the following to cite this dataset:

This data was obtained from the OpenfMRI database. Its accession number is ds000138

Curated:

Yes

Browse Data For All Revisions on S3

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Revision: 2.0.0 Date Set: May 16, 2017, 5 a.m.

Notes:

- Converted to BIDS

Revision: 1.0.0 Date Set: Sept. 24, 2014, midnight

Notes:

- Initial release